Natural Product Library and Metabolite Production Services

Hypha Discovery™ Ltd. is a leading natural products library company, specialising in the identification of novel, biologically active small molecules for pharmaceutical development. Hypha provides small molecule natural products discovery and production services to the pharmaceutical and agrochemical industries.

Our clients and collaborators include academic groups, mid-cap biotech and global pharmaceutical and agrochemical companies.

Hit compound discovery using the MycoDiverse™ natural products screening library

Hypha specialises in the production of novel bioactive small molecule natural products by fermenting a diverse and exotic collection of higher (mushroom) fungi.

The natural products characterised to date from the MycoDiverse™ library of 10,000 fermentation fractions have a very high rate of structural novelty or rarity and with molecular weights mostly between 200 and 400 da are typically smaller than from other sources of natural products.

This library is screened by Hypha’s industrial and academic clients and has out-performed other screening libraries, particularly against “difficult-to-hit” drug targets.

Hypha provides contract fermentation and compound purification services to pharmaceutical and agrochemical companies, usually to supply known literature compounds for lead optimisation.

We also analyse and scale up the production of mammalian metabolites and biodegraded agrochemicals for toxicology and pharmacology evaluation, using our proprietary panels of micro-organisms to biotransform the parent compounds into the target metabolites.

“...They provide a flexible and reliable service, meeting agreed deadlines, and so far have always provided us with the target compounds. We are pleased to recommend Hypha. Certainly we plan to continue to work with them.”
Dianne Irwin, Syngenta

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