Paper Pick – Intestinal Secretion Is a Potentially Important Clearance Mechanism for Low Metabolic Clearance Compounds In this paper, scientists...
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Biocatalytic paths to the synthesis of selected metabolites of Iptacopan In a recent paper published in celebration of the 20th...
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Small but mighty: the impact of tertiary alcohols in drug design By Julia Shanu-Wilson Creating a drug with perfect drug-like...
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Launch of PolyUGTs Kits Our PolyUGTs screening and scale-up kits are now available! They’re a super easy way to make...
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Oxidative biotransformation of elinzanetant to 3 active metabolites Elinzanetant is a dual neurokinin-1,3 receptor antagonist under development for treatment of...
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Welcome to Matt and Xianfu We are delighted that Matthew Allen and Xianfu Li have joined Hypha’s team recently. Xianfu was previously at...
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CYP3A-Mediated Metabolism of Suzetrigine By Julia Shanu-Wilson It’s been more than 20 years since a pain drug with a new...
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Metabolism of 2024 FDA approved small molecules part 1 By Julia Shanu-Wilson Involvement of active metabolites The number of small...
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The Current State of Biotransformation Science Industry Survey of In Vitro and In Vivo Practices, Clinical Translation, and Future Trends...
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Hypha’s Q4 2024 Newsletter – Accessing glucuronides, a new UGT kit and our latest paper picks and blog article Focus topics...
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