WEBINARS
If you missed our webinars on our One-stop Metabolite Shop: “New tools for metabolite synthesis: enhanced PolyCYPs+ kit and late-stage chemical glucuronidation“, but are interested in learning more, please contact us for a link to a recording.
In the webinar our CEO Dr Liam Evans shared Hypha’s new one-stop shop for metabolite synthesis, including our enhanced PolyCYPs®+ screening kits and a new late-stage chemical glucuronidation screen.
The chemical screen is suitable for synthesis of O-, N- and acyl glucuronides and features tailored deprotection strategies suitable for synthesis of acyl glucuronides and some unstable N-glucuronides. The chemical screen is complementary to our existing successful microbial and mammalian biotransformation routes for generating phase II conjugates.
The extended PolyCYPs®+ kits comprise 18 diverse CYP isoforms cloned from some of Hypha’s bacteria, as well as complimentary inclusion of two other phase 1 enzymes – human aldehyde oxidase (AOX1) and flavin monooxygenase 3 (FMO3), with other FMO isoforms to be incorporated as they become available.
CONFERENCES
We will be attending the following meetings in 2020 and 2021
SCI/RSC Applied Late-stage Functionalisation: Where Chemistry meets Biology
18th – 19th February 2020, Manchester, UK
Dr Julia Shanu-Wilson will be giving a talk on “Integration of biocatalysis into medicinal chemistry programs for late-stage oxidation using PolyCYPs enzymes”
260th ACS National Meeting & Exposition
August 16 – 20 2020, San Francisco, USA
Liam will be attending this meeting and giving a talk in the session on “Technologies and Predictive Tools for Metabolite Generation, Identification and Assessment.”
Drug Discovery Chemistry: Lead Optimization for Drug Metabolism & Safety
28th August 2020, San Diego, US
Hypha’s CEO Liam Evans will be attending this meeting which focuses on tools and strategies for predicting, optimizing, and Improving PKPD and safety
5th RSC / DMDG / DMG
New Perspectives in DMPK
4th-5th May 2021, Liverpool, UK.
Julia and Frank will be exhibiting at this meeting and giving a talk entitled “One-Stop Metabolite Shop; Employing Multiple Tools for Accessing Drug Metabolites.”
ACS Medi 37th National Medicinal Chemistry Symposium
27th – 30th June 2021, New York City, USA
Julia and Liam are looking forward to attending this meeting in NYC.