If you missed our webinars on our One-stop Metabolite Shop: “New tools for metabolite synthesis: enhanced PolyCYPs+ kit and late-stage chemical glucuronidation“, but are interested in learning more, please contact us for a link to a recording.
In the webinar our CEO Dr Liam Evans shared Hypha’s new one-stop shop for metabolite synthesis, including our enhanced PolyCYPs®+ screening kits and a new late-stage chemical glucuronidation screen.
The chemical screen is suitable for synthesis of O-, N- and acyl glucuronides and features tailored deprotection strategies suitable for synthesis of acyl glucuronides and some unstable N-glucuronides. The chemical screen is complementary to our existing successful microbial and mammalian biotransformation routes for generating phase II conjugates.
The extended PolyCYPs®+ kits comprise 18 diverse CYP isoforms cloned from some of Hypha’s bacteria, as well as complimentary inclusion of two other phase 1 enzymes – human aldehyde oxidase (AOX1) and flavin monooxygenase 3 (FMO3), with other FMO isoforms to be incorporated as they become available.
We will be attending the following meetings in 2020
18th – 19th February 2020, Manchester, UK
Dr Julia Shanu-Wilson will be giving a talk on “Integration of biocatalysis into medicinal chemistry programs for late-stage oxidation using PolyCYPs enzymes.”