If you missed our webinars on our One-stop Metabolite Shop: “New tools for metabolite synthesis: enhanced PolyCYPs+ kit and late-stage chemical glucuronidation“, but are interested in learning more, please contact us for a link to a recording.
In the webinar our CEO Dr Liam Evans shared Hypha’s new one-stop shop for metabolite synthesis, including our enhanced PolyCYPs®+ screening kits and a new late-stage chemical glucuronidation screen.
The chemical screen is suitable for synthesis of O-, N- and acyl glucuronides and features tailored deprotection strategies suitable for synthesis of acyl glucuronides and some unstable N-glucuronides. The chemical screen is complementary to our existing successful microbial and mammalian biotransformation routes for generating phase II conjugates.
The extended PolyCYPs®+ kits comprise 18 diverse CYP isoforms cloned from some of Hypha’s bacteria, as well as complimentary inclusion of two other phase 1 enzymes – human aldehyde oxidase (AOX1) and flavin monooxygenase 3 (FMO3), with other FMO isoforms to be incorporated as they become available.
We will be attending the following meetings in 2020
18th – 19th February 2020, Manchester, UK
Julia Shanu-Wilson will be giving a talk on “Integration of biocatalysis into medicinal chemistry programs for late-stage oxidation using PolyCYPs enzymes.”
17th April 2020, San Diego, US
Hypha’s CEO Liam Evans will be attending this meeting which focuses on tools and strategies for predicting, optimizing, and improving PKPD and safety
30th April 2020, Hatfield, UK.
Frank Scheffler our Head of Business Development will be attending this great one day meeting in Hatfield catching up on all the recent progress in pharma medchem.
New Perspectives in DMPK
5th-6th May 2020, Liverpool, UK.
Julia and Frank will be exhibiting at this meeting and giving a talk entitled “One-Stop Metabolite Shop; Employing Multiple Tools for Accessing Drug Metabolites.”
June 28 – July 1st 2020, New York City, USA
Julia and Liam will be exhibiting at this meeting.
August 16 – 20 2020, San Francisco, USA
Liam will be attending this meeting and giving a talk in the session on “Technologies and Predictive Tools for Metabolite Generation, Identification and Assessment.”