Accessing FMO-derived metabolites
Metabolites derived from any flavin-containing monooxygenase (FMO) subtype can now be produced as a service offering at Hypha. Recombinant enzymes of all five forms of human FMOs have been cloned into E.coli to provide a mechanism to access scalable quantities of FMO-derived metabolites.
FMO3, the most prominent form in human liver and associated with the bulk of hepatic FMO-mediated metabolism, is also available as part of Hypha’s PolyCYPs+ kit together with 18 PolyCYP isoforms and human AOX1 for accessing phase I oxidised metabolites. FMO3 catalyses N-oxygenation of primary, secondary and tertiary amines, as well as S-oxygenation of nucleophilic sulfur-containing compounds.
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