Free Hypha Webinar: The Power of Biotransformation in Drug Discovery

Join Hypha’s free webinar on 13 October to learn how metabolite identification and synthesis problems can be solved using mammalian and microbial biotransformation, to produce up to gram quantities of challenging phase I metabolites and glucuronides.

Learn also how the technique is supporting medicinal chemists by producing multiple hydroxylated derivatives to improve solubility/polarity (and sometimes potency) of lead candidates.

This biological CH-activation approach is an emerging strategy to boost ligand lipophilicity and for aromatic and aliphatic “late-stage functionalization”, while at the same time highlighting the production of active human metabolites:

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