Contract fermentation, purification and structure elucidation


There is renewed interest in natural products as a source of chemical entities, either through discovery of new scaffolds or re-evaluating previously discovered bioactive chemicals.

Hypha has expertise spanning microbial strain handling, fermentation and improvement, through to the purification and structure elucidation of the target compounds, as well as bioactivity testing. We are able to work flexibly with clients to provide any aspect required.

Examples of projects we can undertake include production of natural product scaffolds for semi-synthetic modification, production and purification of ADC-payloads and purification of bioactive molecules from mixtures. We are able to supply milligram to gram amounts of compounds and have access to multi-thousand litre scale reactors via an alliance with a fermentation provider.


We have extensive experience in natural products chemistry

Download the contract fermentation, purification and structure elucidation brochure >>

Link to a paper describing work we successfully completed on fermentation of the fungus Galiella rufa, from which the client was able to characterise new derivatives.

Why work with us?

  • Our track record in natural products. Our client base of pharmaceutical and agrochemical multinationals and SMEs, is testament to our expertise in fermentation, purification, identification and biotransformation of small molecules.
  • Cost effective, flexible service. Clients may outsource entire programs or choose to work with us on a modular basis.  We can also troubleshoot and rework existing processes and provide a full handover to clients.
  • Our processes are scalable. Target molecules can be produced for further work from mg amounts to assess bioactivity, up to g scale and beyond for semi-synthetic modification.

Contact us to discuss how we can help your project succeed.

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