Microbial Natural Products
Hypha scientists are experts in the discovery, fermentation, purification and structure elucidation of microbial natural products and can support any aspects of projects in these areas. We acquire NMR data through access to a 700 MHz NMR with a 1.7 mm micro-cryoprobe, permitting full structure elucidation on small amounts of material. Our expertise in interpretation of NMR spectroscopic data enable us to elucidate the structures of any new compounds isolated, including the assignment of the correct stereochemistry.
In addition to the discovery of novel natural product structures, we are regularly asked to source known natural products not available to purchase off the shelf. For these projects, we refer back to the original literature in which the compound(s) were first published, and can often improve on the yields reported through application of our fermentation development and molecular biology expertise.
Contact us if you have a project you think we may be able to help with.
Production and purification of microbial natural products
Kebede, B.; Wrigley, S.K.; Prashar, A.; Rahlff, J.; Wolf, M.; Reinshagen, J.; Gribbon, P.; Imhoff, J.F.; Silber, J.; Labes, A.; Ellinger, B. Establishing the Secondary Metabolite Profile of the Marine Fungus: Tolypocladium geodes sp. MF458 and Subsequent Optimisation of Bioactive Secondary Metabolite Production. Mar. Drugs 2017, 15, 84.
Moraes, C. B., Witt, G., Kuzikov, M., Ellinger, B., Calogeropoulou, T., Prousis, K. C., … Gul, S. (2019). Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform. SLAS DISCOVERY: Advancing the Science of Drug Discovery, 24(3), 346–361. https://doi.org/10.1177/2472555218823171
Why work with us?
- Our track record in natural products. Our client base of pharmaceutical and agrochemical multinationals and SMEs, is testament to our expertise in fermentation, purification, identification and biotransformation of small molecules.
- Cost effective, flexible service. Clients may outsource entire programs or choose to work with us on a modular basis. We can also troubleshoot and rework existing processes and provide a full handover to clients.
- Our processes are scalable. Target molecules can be produced for further work from mg amounts to assess bioactivity, up to g scale and beyond for semi-synthetic modification.
Contact us to discuss how we can help your project succeed.