Chemical Synthesis of Drug Metabolites
We have now added chemical synthesis of drug metabolites and conjugates to our capabilities. This provides a comprehensive service for clients to access drug metabolites and derivatives at mg to gram scale under one umbrella, to complement the biosynthetic methods Hypha also provide for difficult-to-synthesise metabolites.
NEW! Late stage chemical screen for synthesis of O-, N– and acyl glucuronides
A proprietary screen consisting of 5 sets of robust and diverse conditions has been developed by Dr Lisbet Kvaerno for synthesising O-, N– and acyl glucuronides of client drug compounds.
Glucuronides are produced direct from the parent compound using tailored deprotection strategies. Using this screen, the structure of the client’s parent drug compound does not need to be revealed. The methods are readily scalable and metabolites can be readily purified by chemists at Hypha.
Case study – Phase I metabolite provision for pharmacology studies
“We worked with Hypha discovery to synthesize metabolites via a chemical approach in enough quantities for pharmacology studies for one of our products. Hypha has well understood our request and has provided a very good quality of service in time, in quantity and quality with the needed level of regular communication. We will work certainly with them in the future and will recommend them.”
Dr. Laure Navarre, Director Process Chemistry, Poxel, France
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